This finding that GW9662 reversed the effects of NCoR ablation reiterates the importance of the PPAR-γ pathway in SSc, confirms that NCoR’s antifibrotic effect in SSc skin fibrosis is mediated primarily by PPAR-γ, and confirms that the PPAR-γ pathway is necessary to resisting fibrogenesis. Here, PPARG is linked to systemic sclerosis.