For candidate CpG analyses, the top hit for both the methylation-25(OH)D association analysis and the breast cancer interaction analyses was cg21201924, located in the gene body of RXRA. As previously noted, RXRA acts as a transcription factor with 1,25(OH)2D and VDR and changes to the gene’s expression and methylation levels could have widespread biological impacts. The gene discussed is VDR; the disease is breast cancer.