The results from Western blotting showed that NME4 and PNPLA7 these two genes were up-regulated significantly and GGT5, PTGS2, IGF1R, NT5C2, ENTPD1 and PTEN these six genes were down-regulated significantly in PBMCs of military pilots with hypertension (Fig. 6). The gene discussed is ENTPD1; the disease is hypertensive disorder.