In AML, it has been shown that JQ1 induces cell death, but little is known about its mechanism [9, 21] Therefore, we examined whether JQ1 induces cell death in AML cells and investigated the underlying mechanism.Four AML cell lines, OCI-AML2, OCI-AML3, MOLM-14, and KG-1, were treated with JQ1 at 300 nM and 600 nM for 48 h prior to analysis with flow cytometry assay. Here, RUNX2 is linked to acute myeloid leukemia.