In AD, H2S showed the ability to ameliorate Aβ-induced cell apoptosis [7], improve spatial memory, and reduce the production of Aβ in the human amyloid precursor protein (Mo/HuAPP695swe) and a mutant human presenilin 1 (PS1-dE9) (APP/PS1) AD mouse model [8]. Here, APP is linked to Alzheimer disease.