High levels of TLR2, TLR3, TLR4, and TLR7 expression have been found in the RA synovium; TLR3 is highly expressed in fibroblast-like synoviocytes (FLS), while TLR2 and TLR4 expression is increased in the perivascular regions of the joint, at the sites of attachment and invasion into cartilage/bone, and on synovial macrophages [11,12]. Here, TLR4 is linked to rheumatoid arthritis.