For instance, EGFR and Her2 signaling have been shown to increase the rate of HIF-1α synthesis and the subsequent expression of survivin and VEGF in breast cancer cells, through the involvement of the PI3k/AKT pathway and the downstream kinase FRAP (FKBP-rapamycin-associated protein) [159]. The gene discussed is AKT1; the disease is breast carcinoma.