HIF-1α has long been recognized as a pivotal orchestrator of the cancer cell responses to hypoxic microenvironment, by regulating the expression of genes involved in metabolic reprogramming and pH balance, cell proliferation/survival, apoptosis, angiogenesis, stem cell maintenance, matrix remodeling, metastasis, and resistance to radio- and chemo-therapy [107]. Here, HIF1A is linked to cancer.