Yet, the authors showed that in the breast cancer cell line HHCC1599, harboring a gene rearrangement of Notch1 causing ligand-independent, but γ-secretase dependent activation of Notch [29], BafA1 had a smaller effect than DAPT in reducing the steady-state levels of NICD and Hes1. The gene discussed is NOTCH1; the disease is breast cancer.