On the other hand, in the hypoxic breast tumor microenvironment, HIF-1α triggers Notch-3 up-regulation toward the decrease of IL-6 levels and the inhibition of the CSCs population, whereas the gamma secretase inhibitors MK-0752 and RO4929097 increase the CSCs population in an IL-6 dependent manner [153]. Here, HIF1A is linked to breast neoplasm.