For instance, the cytokine Oncostatin M, belonging to the Interleukin-6 (IL-6) family of cytokines, enhances HIF-1α protein stability and induces HIF-1α de novo synthesis via activation of mTORC2 in breast Tumor Associated macrophages (TAMs), leading to inflammatory reprograming [144]. This evidence concerns the gene IL6 and breast neoplasm.