Similarly, we found that TGFβ1 could promote the gene expression of cancer stem-like cell markers and increase cell invasiveness in TGFβ1 sensitive NSCLC lines, strongly indicating that TGFβ1 is involved in the generation of cancer stem-like cell subpopulation, which is likely associated with tumor metastasis and recurrence in NSCLC patients. The gene discussed is TGFB1; the disease is neoplasm.