Briefly, we examined gene candidates derived from three separate AIH gene lists produced by studies on AIH onset: 1) 39 genes with segmental duplications among the 8 cases studied here; 2) 21 genes identified in two AIH patient trios with elevated incidence of homozygotes for rare alleles; and 3) genes implicated in AIH by previous studies (HLA-DRB1[17–20], CTLA4 [21,22], FAS [23], VDR [24], TBX21 [25], TNF2 [26], SH2B3, CARD10 [27] and FTCD [28]). The gene discussed is CARD10; the disease is autoimmune hepatitis.