Pik3c2a as well as Foxo4 were regulated by Ikzf1 (linked to type-1 diabetes [37]) whereas Ptf1a was regulated by the Ahr. This suggests essential regulatory roles of Lin-/VEGF-R2+ EPCs’ Foxo4 and Ahr in the early onset of diabetes. Here, PIK3C2A is linked to diabetes mellitus.