Moreover, Ahr is also prominent in the 3-node co-regulatory FFL-motifs (Fig 4) comprising the DE TFs/genes and the miRNAs in the D-EPC-GRN where Ahr activates Foxa2 and Nfkb1. Mir-124 was also found to repress Foxa2 and Ahr as well as Sox9, all of which important key genes in diabetes. This evidence concerns the gene FOXA2 and diabetes mellitus.