The fact that Pik3c2a is up-regulated in Lin-/VEGF-R2+ D-EPCs is supported by studies that demonstrated an inhibitory effect of up-regulated Pik3c2a on epithelial and cancer cell proliferation, migration and colony formation [40] illustrating the observed dysfunction of Lin-/VEGF-R2+ D-EPCs. The gene discussed is PIK3C2A; the disease is cancer.