Thus, in diabetes Pik3c2a enzyme activity is expected to be suppressed, which may result in up-regulation of Foxo1. In our study, both Pik3c2a and Ptf1a (annotated as diabetic-specific genes in the MGI database) were differentially up-regulated in the D-EPC-GRN. The gene discussed is FOXO1; the disease is diabetes mellitus.