The snail, which is zinc finger transcription factors, is overexpressed in epithelial cell lines and mainly repress expression of E-cadherin to reduce cell adhesion during the EMT.[27,28] Therefore, snail is an important factor in regulating EMT and its high expression is related to the enhancement of LC invasion, metastasis, and progression.[29]. Here, SNAI1 is linked to laryngotracheoesophageal cleft.