CDH1 and laryngotracheoesophageal cleft: The metastasis of LC is extremely complex processes, where multiple steps are involved.[22] EMT is considered to be one of the major molecular mechanisms inducing tumor invasion, metastasis, and postoperative recurrence.[23,24] It is an important cellular process, which occurs during cancer development and progression and has a crucial role in metastasis by enhancing the motility of tumor cells.[25] The first step of EMT process is that epithelial cells lose cell–cell junctions and the epithelial marker E-cadherin.[26] E-cadherin acts as a tumor suppressor inhibiting invasion and metastasis.