The Wilms’ tumor 1 (WT1), located at chromosome 11p13, was identified as a gene responsible for the development of Wilms’ tumor at first.[2] During last decades, WT1 has been identified as a contributor to carcinogenesis in various kinds of human cancers including leukemia and myelodysplastic syndromes, brain cancer, neuroblastoma, lung cancer, breast cancer, head and neck squamous cell carcinoma, thyroid cancer, esophageal cancer, renal cell carcinoma as well as in gynecological tumor such as OC, EC, and US.[3–7]. Here, WT1 is linked to head and neck squamous cell carcinoma.