SNCA and Gliosis: Clinically, PD is characterized by pathological changes such as the degeneration and loss of dopaminergic neurons in the midbrain substantia nigra, and gliosis combined with the formation of Lewy bodies (LB), which are the gold standard for PD diagnosis.[3] LBs are mainly constituted by α-synuclein,[4] a protein which consists of 140 amino acids composed of the carboxyl terminal (96–140), the NAC region (6l–95), and the amino terminal (1–60) that plays a particular role in the aggregation of α-synuclein.