POLH and lung cancer: These mild patients usually are not diagnosed timely and own a higher malignancy predisposition, especially to melanoma, SCC and basal cell carcinoma.[6–8] Our patients’ symptoms showed high consistence with XPV and the effective anti-inflammatory treatment and sun-protection measures were also supportive evidence, but the heterogeneous POLH c.1939A>T mutation (already documented in documented in melanoma, nonsmall cell lung cancer, SCC and XPV) and the mutation's existence on the father do not support the diagnosis.[10–12]