According to the current evidence, catheter-directed thrombolysis (CDT) can reduce a clot burden and recurrence of DVT, and consequently prevent the formation of PTS compared with systemic anticoagulation.[3] The present report describes the case of a patient with a PE and massive DVT spreading to the IVC who was treated with both CDT and a factor Xa inhibitor. The gene discussed is F10; the disease is deep vein thrombosis.