The multivariate model identifiedprevious stroke (OR = 10.09; p = 0.016) and elevated levels of pro-B typenatriuretic peptide (proBNP, OR = 1.28 for each 1,000pg/mL increment; p =0.004) as independent predictors of de novo atrialfibrillation. This evidence concerns the gene NPPB and Stroke.