After the selection of the significant predictors in the univariate analysis andtheir application in the multivariable model (Table5), the presence of stroke (OR = 10.09; 95%CI 1.54 - 66.27; p = 0.016)and elevated proBNP values (OR = 1.28; 95%CI 1.086 - 1.520; p = 0.004, for each1,000pg/mL increment) were identified as independent predictors of denovo AF. The gene discussed is NPPB; the disease is stroke disorder.