The medianpeak values of serum creatinine (1.84mg/dL versus 1.22mg/dL) andpeak proBNP (9,461pg/mL versus 1,652pg/mL) were significantlyhigher in patients with de novo AF (p = 0.002 and p < 0.001,respectively). The gene discussed is NPPB; the disease is atrial fibrillation.