In the α-SMAlow domain, CD3+ or CD8+ lymphocytes were fourfold enriched (Figure 9C) and PD-1 and PD-L1-positive cells were 13 to 20-fold more prevalent as compared to the surrounding tumor stroma (α-SMAhigh domain); CD3+ CD8+ double positive T-cells were found almost exclusively in the tumor. Here, CD8A is linked to neoplasm.