Nominally super-resolution imaging on a GE OMX Blaze Structured Illumination Microscope (Carlton et al., 2010) (using a 60 × 1.42 Plan Apo objective) reveals very fine structural details including differential expression of Lamin isotypes (in a melanoma, Figure 2E and Figure 2—figure supplement 2) and mitotic spindle fibers (in cells of a xenograft tumor; Figure 2F and Figure 2—figure supplement 2). Here, LMNA is linked to neoplasm.