Vimentin and E-Cadherin had very different levels of expression in PDAC and normal pancreas as a consequence of epithelial-to-mesenchymal transitions (EMT) in malignant tissues as well as the presence of a dense tumor stroma, a desmoplastic reaction that is a hallmark of the PDAC microenvironment (Mahadevan and Von Hoff, 2007). The gene discussed is VIM; the disease is neoplasm.