For example, plasma lncRNA GAS5 is significantly decreased in the postoperative samples compared with paired preoperative samples, indicating that GAS5 may have the potential to assess the surgical effects for breast cancer.49 Of interest, circulating DNA has been found to be the major form of HOTAIR‐derived fragment in serum, and circulating HOTAIR DNA may be a potential marker for distinguishing breast cancer patients from healthy individuals.50 Taken together, these findings may generate a great enthusiasm in exploring the potential of circulating lncRNAs as minimally invasive markers. The gene discussed is HOTAIR; the disease is breast cancer.