We showed a distinct ion channel gene expression profile as well as reduced sodium and calcium currents in CdCl2‐treated H9‐CMs, suggesting that cells experienced cardiac ion channel remodelling in response to cadmium induction which may account for the altered electrophysiology and cardiac arrhythmias associated with PI3K/Akt and P38 MAPK. Here, AKT1 is linked to chronic obstructive pulmonary disease.