IKBKB and lung adenocarcinoma: For example, IKKα is increased in the vasculature of lung adenocarcinomas, and over‐expression of IKKα, but not IKKβ, in HUVECs promotes in vitro angiogenesis.10 In contrast, homozygous deletion of IKKβ in endothelial cells disrupts placental vascularization and impairs EC survival and migration.11 Taken together, these data suggested that IKKα and IKKβ may direct independent functions in the vasculature, with each kinase serving as the predominant regulator of angiogenesis depending on the tissue type and/or stage of development.