HIF2α and Jagged1 expression correlated significantly in all tumor types analyzed (renal cancer, n = 209, R2 = 0.65, p < 2.2 * 10−16; breast carcinoma, not otherwise specified (NOS), n = 553, R2 = 0.43, p < 2.2*10−16; ductal breast cancer, n = 327, R2 = 0.39, p < 1.8 * 10−13, breast cancer, others, n = 15, R2 = 0.64, p < 0.01; neuroblastoma, n = 123, R2 = 0.50, p < 4.0 * 10−9; medulloblastoma, n = 62, R2 = 0.36, p = 0.0043; Fig. 1k, Supplementary Figure 1E). Here, EPAS1 is linked to breast carcinoma.