EPAS1 and medulloblastoma: In medulloblastoma DAOY cells, as well as in MCF7 cells, expression of cytoplasmic NERT2 did not enhance HIF2α or NRARP expression, whereas tamoxifen-induced nuclear localization of NERT2 for 8 h led to a robust upregulation of HIF2α and NRARP expression (Fig. 2b, Supplementary Figure 2A).