On the other hand, in MDA-MB-435 s, which is another invasive breast cancer cell line, the knockdown of AMAP1, Arf6, ILK, or TRAK1 significantly inhibited mitochondrial distribution (Fig. 7d–f), suggesting that this molecular axis is indeed commonly used in highly invasive cells for regulating mitochondrial distribution. The gene discussed is TRAK1; the disease is breast carcinoma.