APP and Alzheimer disease: Importantly, neither AD1 nor AD2 evinced any sign of overt perikaryal loss, and the number of cell body clusters remained constant throughout the course of the experiments and did not differ from the corresponding ID-AD or media controls (Supplementary Figure 8C) (AD1, AD vs ID, p = 1.0000; AD2, AD vs ID, p = 0.0745, two-way ANOVA).