We also compared a BRCA1-mutated, PARPi-sensitive triple negative breast cancer (TNBC) cell line, MDA-MB436, to a BRCA-proficient TNBC cell line, HCC114353, and observed PARPi-induced γH2AX in MDA-MB436 but not in HCC1143 cells, consistent with their PARPi-sensitivity status (Fig. 2d). This evidence concerns the gene BRCA1 and triple-negative breast carcinoma.