HIF‐1α is critical for cancer cell survival and metastases in the solid tumour under stressed hypoxic tumour environment, in part by inducing glycolytic enzymes and EMT process.21, 22, 23 It could up‐regulate a series of glycolytic genes during anaerobic glycolysis and then increase the glycolysis rate and ATP production. The gene discussed is HIF1A; the disease is neoplasm.