SESN2 and cancer: Cancer cells develop adaptive responses to hypoxia by activating the hypoxia‐inducible genes to overcome this harsh environment.8, 9, 10 Under this circumstance, hypoxia is a major characteristic of cancer; in hypoxic conditions, cancer cells develop metabolism reprogram from oxidative phosphorylation to glycolysis.11, 12 A feature of this phenomenon is increased lactate production even at normal oxygen concentrations.