NDUFB6, a component of respiratory chain complex I (RCI), is located in the mitochondria (Loublier et al., 2011) and plays an important role in electron transfer activity (Dieteren et al., 2011). RCI dysfunction may contribute to tumor progression by enhancing the metastatic potential of tumor cells (Narimatsu et al., 2015). Here, NDUFB6 is linked to neoplasm.