The tumor microenvironment might be immunosuppressive, while the M2 tumor‐associated macrophage phenotype might contribute to the further development of OSCC.5 In addition, the immunosuppressive effect of OSCC is related to the high expression of the programmed cell death ligand 1 (PD‐L1).6, 7 PD‐Ll is an important immunological checkpoint protein that binds to programmed cell death protein 1 (PD1) expressed on immune cells, such as activated T cells, by inhibiting the activation and proliferation of T cells.8 This evidence concerns the gene CD274 and neoplasm.