HSF1 and Myocardial fibrosis: Our group, together with the others, previously reported that HSF1 plays an important role in the myocardial protection against cardiac overload.5, 21 Although the beneficial effects of HSF1 were largely attributed to the decreases of myocardial fibrosis in long‐term of biochemical stress such as pressure overload and ischaemia/reperfusion injury,6 the cellular and molecular mechanism of the protective role of HSF1 in the pathological cardiac remodelling led by direct ischaemia is still undetermined.