IRS1 and non-small cell lung carcinoma: Its specific amino acid residues respectively bind to intracytoplasmic insulin receptor substrate 1 (IRS1), v‐src sarcoma [Schmidt‐Ruppin A‐2] viral oncogene homolog [avian] (SRC) and SRC homology 2 domain‐containing (SHC), and sequentially activate Ras/ERK pathway, simultaneously activate mTOR and its downstream ribosomal protein S6 kinase (p70S6K) and S6 ribosomal protein (S6RP), in final stimulate gene transcription and promote ribosome formation.76 Besides STAT3 and extracellular signal‐regulated kinase (ERK), PI3K also took part in regulation of ALK+ NSCLC survival and anti‐apoptosis.