Metastasizing melanoma cells obtain blood supply in two ways generally, one is keeping close contact to microvessels and another is perivascular growth by vessel co‐option.98 For example, the activation of STAT3 would stimulate vascular remodeling and promote BM through increased expression of basic fibroblast growth factor (bFGF), VEGF, and MMP‐2.97 Connexin 26 (Cx26) is also involved in vessel co‐option during MBM.99 This evidence concerns the gene MMP2 and melanoma.