The lack of a relationship between high‐grade disease and IGF‐1 has also been implied in other reports.34 The PI3K/AKT pathway is inhibited by phosphatase and tensin homolog (PTEN), which is a tumor suppressor.35 A previous study reported that complete loss of the PTEN gene is more frequent in high‐grade prostate cancer,36 in which, the PI3K/AKT pathway is constitutively active and requires minimal activation by IGF‐1 or other hormones. Here, PTEN is linked to Familial prostate cancer.