When the men with prostate cancer were divided into four categories according to these cut‐off values (Figure 2), the risk of high surgical GS was highest (OR = 2.285; 95% CI, 1.066‐4.897) in patients with low bioavailable testosterone (≤0.85 ng/mL) and low IGF‐1 (≤116.0 ng/mL), and was less when the level of either bioavailable testosterone (OR = 1.968; 95% CI, 1.045‐3.704) or IGF‐1 was low (OR = 2.205; 95% CI, 1.442‐3.371; Figure 2). The gene discussed is IGF1; the disease is prostate cancer.