CNR1 and colorectal carcinoma: In an animal model, it reduced ACF (preneoplastic lesions), polyps, and tumor formation and counteracted colon cancer-induced changes in gene expression.9 A CBD-rich cannabis extract also was shown to inhibit CRC cell proliferation and attenuate colon carcinogenesis.10 This activity involved both CB1 and CB2 receptor activation.10 Cannabigerol (CBG) promoted apoptosis, stimulated reactive oxygen species (ROS) production, and reduced cell growth in CRC cells.