TNF and colorectal carcinoma: Also, elevation in colonic TNF-α leads to protransformational alterations of key components of the Wnt signaling pathway.37 Interestingly, in our study where cells are also treated with TNF-α, treatment with F7+F3 resulted in differential expression of genes related to the Wnt signaling, suggesting that this treatment may counteract TNF-α-induced CRC.