BCL2 and neoplasm: PUMA (geneID: 27113, BCL2-binding component 3) BH3-only Bcl-2 family proteins is a p53 downstream target and acts as a mediator for different tumor suppression drugs that treat CRC.41 PUMA expression is induced by F7+F3 cell treatment and may indicate the potential to increase PUMA-regulated treatment of CRC by treatment with the combination of F7+F3 and the relevant drugs.