MAP1LC3A and cancer: In fact, changes of autophagic activity have been observed in a large number of tumors, and the expression levels of the autophagy-related protein LC3 differ among different tumors, including a smaller number of reports in brain tumors and lung, cervical, and ovarian cancer [18, 19] and more reports in cancers of the esophagus and the gastrointestinal tract [20, 21].