In a study by Kabbabe et al. [17], quantitative PCR was used to show increased expression levels of (i) MMP-3 and (ii) A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS 4) as a fibrogenic mediator in a FS group compared with a control group. The gene discussed is MMP3; the disease is Feingold syndrome.