Finally, also in the frame of endothelial dysfunction, in which, as discussed above, the imbalance in eNOS and iNOS functionality leads to increase in oxidative damage of the liver vasculature leading to inflammation and fibrosis, our group recently published a paper demonstrating that systemic eNOS impairment is significantly associated with NAFLD [118]. The gene discussed is NOS3; the disease is metabolic dysfunction-associated steatotic liver disease.