Interestingly, five of these loci showed pleiotropy with IBD: MGAT3, a glyco-gene encoding for a glycosyltransferase, GnT-III; LAMB1, a member of transmembrane glycoprotein family of extracellular matrix; the IL6ST, a signal transducer shared by many cytokines; IKZF1; and BACH2, transcription factors involved in B cell differentiation, activation, and maturation. Here, IL6ST is linked to inflammatory bowel disease.