Among ADIPOQ single nucleotide polymorphisms (SNPs), two SNPs, rs2241766 (+ 45T/G in exon 2) and rs1501299 (+ 276G/T in intron 2) have been studied mainly for their association with circulating adiponectin, obesity, IR, T2DM, and CVD risk [15, 16]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.