In addition, the ADIPOQ rs2241766-rs1501299 haplotype is linked to plasma adiponectin levels and the progress of MetS [16, 18]: TT/TT subjects (T/T at both rs2241766 and rs1501299) showed significantly higher adiponectin levels and lower IR than did other carriers among nonobese and nondiabetic men [18]. This evidence concerns the gene ADIPOQ and metabolic syndrome.