PDCD4 and myocardial ischemia: MiR-21 also has a protective role in cardiomyocyte apoptosis after myocardial ischemia– reperfusion (I/R) injury through the PTEN/Akt signaling pathway and suppression of FasL, as well as in H2O2-induced cardiac cell death and apoptosis via its target gene programmed cell death 4 (PDCD4)15–17.