To explore the possibility of intrinsic CCL5-deficiency in CD8+ T cells to affect the migration and antitumor activity of CD8+ T cells, we adoptively transferred CCL5+/+ CD8+ T cells or CCL5−/− CD8+ T cells isolated from tumor-bearing mice into CCL5−/− mice or CCL5+/+ mice, respectively. Here, CD8A is linked to neoplasm.