In this respect, audiogenic kindling, firstly described by Marescaux et al. 6 and its electrophysiological counterparts subsequently reproduced in Genetically Epilepsy-Prone Rats (GEPRs) by Naritoku et al. 7 and in WARs by Dutra Moraes et al. 8 could be considered as a model of limbic recruitment or TLE4,8, the most common epilepsy syndrome in human adults19, in which a massive activation of limbic structures can be observed during seizures. The gene discussed is TLE4; the disease is epilepsy syndrome.