CAV1 and brain inflammatory disease: The inhibition of inflammation by Cav-1 has been demonstrated in different cells and animal models: Cav-1 overexpression decreased LPS-induced inflammation in macrophages54; Cav-1 scaffolding domain peptide inhibited psoriasis-like skin inflammation induced by imiquimod55; Cav-1 deletion aggravated brain inflammation induced by traumatic brain injury24 and lung inflammatory response to LPS56.