ASAH1 and preeclampsia: Moreover, Melland-Smith et al. [19] recently elucidated that the combination of ceramide-mediated autophagy activation and oxidative stress-reduced hydrolase activity impaired placental function in preeclampsia which were accompanied by a reduction in N-acylsphingosine amidohydrolase 1, which catalyzes the degradation of ceramide into sphingosine and free fatty acid.