CK20 and CK5/6 were included in this study as these immunostains have previously been used to distinguish basal and luminal MIBC subtypes.12 MRE11, p53, p21, TIP60 and Ki67 IHC have previously been investigated in MIBC and found to be potentially associated with survival and/or cancer progression.13–20 However, there is currently not enough evidence to conclude whether these proteins are valid biomarkers for DSS in MIBC. The gene discussed is MKI67; the disease is cancer.