The 2016 World Health Organization (WHO) classification of hematopoietic and lymphoid tumors defines five subtypes of MPAL: MPAL with t(9;22)(q34;q11.2), MPAL with MLL rearrangement, MPAL B/myeloid not otherwise specified (NOS), MPAL T/myeloid NOS, and MPAL NOS rare types2. The gene discussed is KMT2A; the disease is mixed phenotype acute leukemia.