SOCS1 and acute myeloid leukemia: Combined with results from Fig. 1, one can deduce that low CUEDC2 expression was a key reason for ubiquitin-mediated degradation of SOCS1 in AML cells without SOCS1 promoter methylation, and CUEDC2 was a potential regulator of the ubiquitin-mediated degradation of SOCS1.