KMT2A and leukemia: Similarly, correlations between SOCS1 expression and its promoter methylation with primary AML cells subtypes were also analysed; leukaemia with normal karyotype displayed the highest level of SOCS1 promoter methylation (87.07%, n = 116) among all detected primary AML cells subtypes, followed by t(15;17) AML (80.52%, n = 77), complex AML (80%, n = 45), t(11q23)/MLL AML (38.23%, n = 34), t(8;21) AML (23.81%, n = 63) and inv(16)/t(16;16) AML (14.29%, n = 56) (data not shown).