Furthermore, information about lineages of primary AML cells exhibiting reduced SOCS1 expression was also summarised, our results indicated that inv(16)/t(16;16) AML (n = 56) displayed the most obvious reduction in SOCS1 levels among all detected primary AML cell subtypes, followed by t(8;21) AML (n = 63), t(11q23)/MLL AML (n = 34), t(15;17) AML (n = 77) and complex AML (n = 45) (data not shown). The gene discussed is KMT2A; the disease is acute myeloid leukemia.