There was a prevalence of TP53 mutations in exon 7 (5/12, 42%), with two of these occurring at codon 245, a known hotspot in S-CRC.28 It is noteworthy that in case UC07, the LGD biopsy displayed a TP53 p.R306X mutation, yet this variant was absent in the carcinoma itself, where instead a TP53 splice site mutation was detected. This evidence concerns the gene TP53 and colorectal carcinoma.