At the molecular level, the sequence of events leading to CA-CRC is distinct from S-CRC: most notably TP53 mutation is typically an early event in the former, detected in precancerous neoplasms10 or even in non-neoplastic mucosa,11 12 whereas TP53 mutations are rare in the adenomatous precursors of S-CRC.13 14 Aneuploidy can be present in non-dysplastic colitic epithelium,15 16 suggesting a role for chromosomal instability early in the genesis of CA-CRC. The gene discussed is TP53; the disease is cancer.