Also of interest is the gene CDH2 (N-cadherin), as the expression of mutant N-cadherin in mouse small intestine has been shown to induce a Crohn’s-like phenotype.30 Other notable genes that were mutated in at least 30% of CA-CRC, but mutated at very low frequency in S-CRC included POLG (DNA polymerase gamma, involved in mitochondrial DNA replication) and PAXIP1 (involved in maintaining genome stability). The gene discussed is POLG; the disease is colorectal carcinoma.