Other common S-CRC driver genes that were mutated at similar frequency in our CA-CRC cohort included KRAS (CA-CRC=40% vs S-CRC=43%, q=1.0), PIK3CA (20% vs 13%, q=0.9) and FBXW7 (30% vs 11%, q=0.2). This evidence concerns the gene KRAS and colorectal carcinoma.