It is notable that 5q22.2 (APC) allelic loss is more common in CA-CRC (9/20 cases, 45%) than in MSS S-CRCs (42/189, 22%, TCGA data,23 p=0.051 by Fisher’s test), perhaps indicating that Wnt signalling in CA-CRCs is disrupted by copy loss of APC rather than mutation. This evidence concerns the gene APC and colorectal carcinoma.