ERK (also known as EPHB2) signalling is another example of glutamine-dependent activation found in intestinal epithelial cells (Rhoads et al., 1997; Larson et al., 2007), and in melanoma (Pollock et al., 2003; Ohtani et al., 2008) and glioma cells (Arcella et al., 2005). This evidence concerns the gene EPHB2 and melanoma.