ALOX5 and neoplasm: Other lipid metabolism enzymes, such as arachidonic acid 5-lipoxygenase (ALOX5), which is involved in the synthesis of leukotrienes (Box 1) from arachidonic acid, and acyl-CoA synthetase very-long-chain 3 (ACSVL3; also known as SLC27A3), a key enzyme in fatty acid activation for the formation of fatty acyl-CoA, were also shown to support glioblastoma CSCs self-renewal and to induce tumour xenograft formation (Wang et al., 2011; Sun et al., 2014).