Genes involved in glycolysis, namely PKM2 and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), were also identified as stemness regulators in glioma SCs (Morfouace et al., 2014) (Fig. 1A). The gene discussed is PFKFB4; the disease is central nervous system cancer.