Although some studies showed that PKM2 benefits tumor growth by increasing the flux through anabolic pathways (Christofk et al., 2008a; Lunt et al., 2015), others suggest that PKM2 is not an obligatory factor for tumor formation (Cortés-Cros et al., 2013; Dayton et al., 2016a; Israelsen et al., 2013). This evidence concerns the gene PKM and neoplasm.