In fact, various forms of Tau aggregation account for more than 20 neurological disorders include AD, frontotemporal dementia with parkinsonism-17 (FTDP-17), progressive supranuclear palsy, corticobasal degeneration, argyrophilic grain disease, chronic traumatic encephalopathy and Parkinson’s disease (PD) [3, 4]. The gene discussed is MAPT; the disease is Alzheimer disease.