The 2N4R Tau composes 85 putative phosphorylation sites (45 serines, 35 threonines, and 5 tyrosines), in which 17 Thr-Pro (T/P) or Ser-Pro (S/P) motifs are abnormally hyperphosphorylated in the AD and other tauopathy conditions [59]. The gene discussed is MAPT; the disease is Alzheimer disease.