Knockdown of PTBP1 prevented SASP induction in response to doxorubicin in IMR90 cells (Figures 3G and S3C), irradiation in human fibroblasts (Figure S3D), and oncogenic HER2 expression in MCF7 breast cancer cells (Figure S3E), without reverting the growth arrest (Figures 3G, S3D, and S3E). Here, PTBP1 is linked to breast carcinoma.