For overproduction of pro-inflammatory cytokines such as ILs, TNF-α, IFN-γ and TGF-β is known to occur in severe DENV [146], WNV [147] and YFV [148] leading to cytokine storm and vasculopathy, hemorrhage, tissue damage and septic shock characteristic of severe flavivirus infections. The gene discussed is TGFB1; the disease is vascular disorder.